Genetic Polymorphisms in a 1
نویسندگان
چکیده
The widely expressed chicken UBTD2 gene in different types of tissues from embryonic to adult developmental stages implies its important role in regulating protein ubiquitination and delivery of ubiquitinated substrates, however, there is no specific study on the genomic DNA structure and function of chicken UBTD2 gene except a few invalidated SNPs derived from ESTs. In this study, a 1.2 kb long fragment within intron 2 of chicken UBTD2 gene was amplified and directly sequenced from a flock of 11 White Leghorn chickens. A total 15 sequences were identified from these birds, of which seven were homozygous but the remaining four were heterozygous. These new sequences were analyzed together with the homologous region in Gallus gallus reference genome version 71.4 (Chromosome 13: 8104760 8105979 in Galgal4). There were 10 polymorphic sites including seven transitions and three transversions, which defined four haplotypes in these 16 sequences. The Gallus gallus reference sequence formed a specific and distinct haplotype while the White Leghorn chickens carried three haplotypes at very similar frequencies of four, five and six sequences each. These data were the first piece of evidence of genetic polymorphisms present in the chicken UBTD2 gene which is therefore warranted for further investigation on the functional diversity in its complete genomic DNA sequence of different genetic backgrounds.
منابع مشابه
Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer’s Disease Using Logic Regression
Objectives: Genetic polymorphism interactions are among the important factors in affliction with complex diseases like Alzheimer’s disease. The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases. In this study, feature selection approach of logic regression was used to ide...
متن کاملGenetic Polymorphisms within The Intronless ACTL7A and ACTL7B Genes Encoding Spermatogenesis-Specific Actin-Like Proteins in Japanese Males
Actins play essential roles in cellular morphogenesis. In mice, the t-actin 1 and 2 genes, which encode actin-like proteins, are specifically expressed in haploid germ cells. Both T-ACTIN 1/ACTLB and T-ACTIN 2/ACTL7A have also been cloned as orthologous genes in humans; they are present on chromosome 9q31.3 as intronless genes. Defects of germ cell-specific genes can introduce infertility witho...
متن کاملP-206: Mov10l1 Gene Polymorphisms Are Probably Associated to Male Infertility in Azoospermic Men with Complete Maturation Arrest
Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...
متن کاملGenetic polymorphisms in the promoter region of catalase gene, creates new potential PAX-6 and STAT4 response elements
Catalase (CAT, OMIM: 115500) is an endogenous antioxidant enzyme and genetic variations in the regulatory regions of the CAT gene may alter the CAT enzyme activity and subsequently may alter the risk of oxidative stress related disease. In this study, potential influence(s) of the A-21T (rs7943316) and C-262T (rs1001179) genetic polymorphisms in the CAT promoter region, using the ALGGEN-PROMO.v...
متن کاملOmentin-1 rs2274907 and resistin rs1862513 polymorphisms influence genetic susceptibility to nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated disease and dysregulation of adipokines has an important role in its development. Omentin-1 (ITLN1 protein) and resistin are two adipokine secreted from adipose tissue. Single nucleotide polymorphisms in the adipokine genes may affect expression and activity of the adipokine, and thus play a contributory role in NAFLD pathogenesi...
متن کامل